Incidence of clostridium perfringens and its toxin genes in the gut of children with autism spectrum disorder
Excess inflammation is a well-known contributor to aging, as it can damage tissues and organs over time
M.Vzquez-CarradaM.Uribe-RamrezD.Matuz-MaresD
ACSL4 catalyzes the reaction of PUFAs to polyunsaturated fatty acid-coenzyme A (PUFA-CoA), and then the PUFA-CoA undergoes esterification by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to become polyunsaturated fatty acid-phospholipids (PUFA-PLs), which are then oxidized by reactive oxygen species (ROS) to cytotoxic phospholipid hydroperoxides (PL-OOH), leading to cell death through membrane modification (Liu et al., 2025
Neptun showed an increased expression of glutathione transferase StGSTF2 and a general activity of GST, corresponding with an increase in the GSSG form and indicating involvement in the resistance reaction
This, in turn, would drive oxidatively induced cell death and increase barrier dysfunction and T2 inflammation, potentially identifying a mechanism by which viruses cause asthma exacerbations